Volume 54, Issue 3, 10 February 2026

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NAR Breakthrough Article

Transient acute neuronal activation response caused by high concentrations of oligonucleotides in the cerebral spinal fluid

Mariana Bravo-Hernandez and others

Critical Reviews and Perspectives

Constant trouble with prolines'navigating a global translation dilemma

JÃ¼rgen Lassak and others

Unlocking the full potential of nanopore sequencing: tips, tricks, and advanced data analysis techniques

Daria Meyer and others

Chemical Biology and Nucleic Acid Chemistry

Aspergillus fumigatus PolX1 is an early ancestor of vertebrate terminal deoxynucleotidyl transferases

Najma Parveen and others

METTL1 interacts with XPO5 to modulate pre-miRNA export

Zhongwen Cao and others

From alkylating to shape-shifting G-quadruplex ligands: the RHAU peptide story

Lessandro De Paepe and others

i-Motif, not G-quadruplex, stability regulates insulin expression

Dilek Guneri and others

Indirect identification of genomic G-quadruplexes via a small protein probe that specifically recognizes C-rich single-stranded DNA

Juan-nan Chen and others

Computational Biology

Expanding the landscape of BREX diversity: uncovering multi-layered functional frameworks and identification of novel BREX-related defense systems

Siuli Rakesh and Arunkumar Krishnan

Computational evolution of poly(U) polymerase for efficient and controlled RNA oligonucleotide synthesis

Lixiang Yang and others

Data Resources and Analyses

PlasAnn: a curated plasmid-specific database and annotation pipeline for standardized gene and function analysis

Habibul Islam and others

The transcriptional regulatory network of the Escherichia coli MG1655 reference strain

Heera Bajpe and others

Gene Regulation, Chromatin and Epigenetics

Phosphorylation of Barrier-to-Autointegration Factor (BAF) regulates anchoring of centromeric heterochromatin to the nuclear envelope (NE)

Monica Torras-Llort and others

Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise

Emily A Warman and others

ZINC FINGER PROTEIN 1 and 8 interact with polycomb repressive complex 2 to repress class B and C floral organ identity genes

Tieqiang Hu and others

A novel dual histone mark reader ZCWPW2 regulates meiotic recombination through lactylation and transcriptional regulation in humans and mice

Tiechao Ruan and others

Ultra-low-input rG4-seq reveals the RNA G-quadruplex regulome in gene expression and genome integrity

Tie-Gang Meng and others

LDB1 regulates gene expression and chromatin structure in pluripotency and lineage differentiation

HeungSun Kwon and others

Separate transcription and splicing gene networks are linked and coordinated by the pRb'E2F pathway

Simon M Carr and others

A new set of combinatorial dimeric codes for nuclear hormone receptor'target gene specificity

Xin Wang and others

Splicing regulation and intron evolution in the short-intron ciliate model of endosymbiosis Paramecium bursaria

Thi Ngan Giang Nguyen and others

Yeast condensin acts as a transient intermolecular crosslinker in entangled DNA

Filippo Conforto and others

Genome Integrity, Repair and Replication

Transcription termination counteracts DNA damage after WEE1 inhibition

Helga B Landsverk and others

KIF2A-mediated microtubule-dependent nuclear envelope invagination drives nonhomologous end joining

Yujie Ma and others

Mycobacterial non-homologous end joining is required for antiphage defense

Yu Huang and others

Molecular and Structural Biology

Structural plasticity enables broad cA_n binding and dual activation of CRISPR-associated ribonuclease Cdn1

Wenxuan Zhang and others

Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11's role in cooperative recognition of diverse targets

Xuehui Bai and others

Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 3₁ and 5₂ knots

Zhuwei Zhang and others

Structures of naked mole-rat, tuco-tuco, and guinea pig ribosomes'is rRNA fragmentation linked to translational fidelity?

Cristina Gutierrez-Vargas and others

The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments

Ibraheem Alshareedah and others

Conformational dynamics of CRISPR'Cas type I-F-HNH inform nickase engineering in a cascade scaffold

Anders Fuglsang and others

Zinc-finger transcription factor Fzf1 binds to its target DNA in a non-canonical manner

Chaoqun Ma and others

Pentanucleotide guanine-rich WGGGW repeats, including CANVAS AGGGA repeats, form a variety of noncanonical structures

Jiawei Wang and others

Epitranscriptomic control of stress adaptations in Escherichia coli

SebastiÃ¡n Riquelme-Barrios and others

Nucleic Acid Enzymes

The GT1 domain of RNase J ensures RNA quality control through dsRNA binding in Arabidopsis plastids

Kevin Baudry and others

Photoclick chemistry led to the identification of HELLS as a helicase for DNA G-quadruplexes

Zi Gao and others

Critical structural perturbations of ribozyme active sites induced by 2²-O-methylation commonly used in structural studies

SÃ©lÃ¨ne Forget and Guillaume Stirnemann

Cleavage of host tRNAs by mycoplasma membrane-associated nuclease

Yasutoshi Akiyama and others

Specificity of DNA targeting by RNA-guided pAgo nucleases

Lidiya Lisitskaya and others

Nu"/>cleic Acid Therapeutics

Staufen dsRNA-binding domain as modules to design bifunctional antibodies for siRNA delivery

Yahui Liu and others

Heteroduplex oligonucleotide technology boosts gene knockdown in cardiac and skeletal muscles

Sakino Matsuda-Kawabata and others

Acute neuronal inhibition response caused by phosphorothioate antisense oligonucleotides following local delivery to the central nervous system

Jacqueline G O'Rourke and others

RNA and RNA-protein complexes

Transcriptome-wide analysis of Arabidopsis DICER-LIKE1 RNA substrates

Nicolas G Bologna and others

A comprehensive view on r-protein binding and rRNA domain structuring during early eukaryotic ribosome formation

Magdalena Gerhalter and others

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA export

Nataliia Stefanyshena and Katja StrÃ¤ÃŸer

NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes

Marie B A Peters and others

Sni445 recruits box C/D snoRNPs snR4 and snR45 to guide ribosomal RNA acetylation by Kre33

Jutta Hafner and others

Yeast elongation factor homolog New1 protects a subset of mRNAs from degradation by no-go decay

Max MÃ¼ller and others

AURKB-driven dissolution of CIZ1'RNA assemblies from the inactive X chromosome in mitosis

Lewis Byrom and others

Fibrillarin/Nop1 perturbs RNA folding and assembly independently of liquid'liquid phase separation

Yunsheng Sun and Sarah A Woodson

A non-canonical role for HIF-1alpha : redirecting DGCR8 to the RNA exosome for snoRNA degradation and translational modulation

Jie-Ning Li and others

Functional characterisation of tumour suppressor PDCD4 reveals previously undisclosed role in the control of cell adhesion

Veronica Dezi and others

Methods

ADAM-tRNA-seq: an optimized approach for demultiplexing and enhanced hierarchal mapping in direct tRNA sequencing

Rodrigo Alarcon and others

Genome-wide extraction of differentially methylated DNA regions using adapter-anchored proximity primers

Farzaneh Darbeheshti and others

PCLIPtools: a robust framework for identifying RNA-protein interaction sites from PAR-CLIP experiments

Ahsan H Polash and Markus Hafner

Corrections

Correction to ˜RBPWorld for exploring functions and disease associations of RNA-binding proteins across species'

Correction to ˜DNA extrusion size determines pathway choice during CAG repeat expansion'

Correction to ˜The early injected genomic region determines sensitivity to Type I restriction-modification defence against Autographiviridae phages'

Correction to ˜Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor'

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