Volume 54, Issue 1, 13 January 2026
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Critical Reviews and Perspectives
Unravelling the noncanonical extracellular DNA structures in biofilm and NETosis
Tevriz Dilan Demir and others
Chemical Biology and Nucleic Acid Chemistry
Directed evolution on compact landing pads yields highly efficient recombinases for large DNA integration
Hanseop Kim and others
Allele-specific knockdown by an engineered DNAzyme capable of RNase H1 evasion
Erica M Lee and others
A universal kinetic framework for quantitative isothermal amplification governed by polymerase speed, amplicon size, and binding efficiency
Langjun Tang and others
Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA
Lachlan B Cox and others
Junction-targeting designs limit the application of CRISPR-Cas13d in circular RNA perturbation studies
Yannick C Lee-yow and others
Recognition of unnatural base pairs by a eukaryotic DNA polymerase enables universal sequencing of an expanded genetic alphabet
Hantao Luo and others
Presence of phosphodiester backbone, but not nucleobases, in the guide's 3 terminal region is necessary for RISC loading and target cleavage
in vitro
and
in vivo
Daniel O'Reilly and others
Computational Biology
Uncovering coordinated pathway interactions through gene co-differential expression in yeast
Muhammad Ibtisam Nasar and others
A structure-guided approach to noncoding variant evaluation for transcription factor binding using AlphaFold 3
Lukas Gerasimavicius and others
scSuperAnnotator: a platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data
Qi Qi and others
A network-based model of
Aspergillus fumigatus
elucidates regulators of development and defensive natural products of an opportunistic pathogen
Cristobal Carrera Carriel and others
Data Resources and Analyses
Protein structure-informed bacteriophage genome annotation with Phold
George Bouras and others
DNATCO v5.0: integrated web platform for 3D nucleic acid structure analysis
Jiří 'erný and others
Gene Regulation, Chromatin and Epigenetics
No evidence for the putative nitric oxide sensor NsrR as a key regulator of magnetosome formation in
Magnetospirillum gryphiswaldense
Alexandra Woller and others
Systemic control of HNF1B-driven redox homeostasis by
N
6
-adenosine methylation
Minji Park and others
Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen
Slavica Janevska and others
Phosphorylation-dependent modulation of the Lamin A/C'EZH2 complex regulates epithelial'mesenchymal plasticity
Balaji AK and others
YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment
Zhiming Wang and others
A conserved 3UTR short motif regulates gene expression in vertebrates
Ana Eufrásio and others
RNA polymerase II degradation triggered by DNA repair occurs
in trans
and independently of how the lesion is recognized
Ramveer Choudhary and others
Activation of bacterial transcription by distortion of promoter base pairing
Ksenia M Klimova and others
Effector gene silencing coordinated by histone methylation and small RNAs enhances host adaptation in a plant pathogen
Liyuan Wang and others
Sequence-dependent co-condensation of Lsr2 with DNA elucidates the mechanism of genome compaction in
Mycobacterium tuberculosis
Prakshi Gaur and others
Co-transcriptional splicing changes combine with reduced productive transcription initiation for cold-induced repression of
FLC
Robert Maple and others
Dual transcriptional and post-transcriptional regulation by the bHLH proteins Rtg1 and RtgX in
Komagataella phaffii
Neetu Rajak and others
Linker histone H1.5 contributes to centromere integrity
Ankita Saha and others
HLTF cooperates with GATA1 to activate transcriptional programs and chromatin remodeling during erythroid development
Han Gong and others
Genome Integrity, Repair and Replication
PARP1 and PARP2 are dispensable for DNA repair by microhomology-mediated end-joining at double-ended DSBs
Raquel Ortega and others
PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: implications for the interplay between human DNA damage tolerance pathways
Jessica L Norris and others
A mechanism for telomere-specific telomere length regulation
Gabriela M Teplitz and others
Transcriptional PBR cycles at pericentromeric repeats cause gross chromosomal rearrangements through Rad52-dependent ADR-loop formation
Ran Xu and others
Genomics
Replication stress increases
de novo
CNVs across the malaria parasite genome
Noah Brown and others
Molecular and Structural Biology
Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition
Kazuki Ishihara and others
Beyond DNA binding: single C2H2 zinc fingers with adjacent beta -strands mediate dimerization in
Drosophila
transcription factors
Konstantin I Balagurov and others
An N-terminal helix of Lsm11 stabilizes CPSF73 in U7 snRNP for histone pre-mRNA 3-end processing
Anthony Desotell and others
Structural evolution of the selectivity clamp confers ADPR-PP specificity in Namat, a phage nicotinamide ADP-ribose transferase
Meimei Lan and others
Multimodal bHLH-PAS DNA binding controls specificity and drives obesity
David C Bersten and others
New targets and procedures for validating the valence geometry of nucleic acid structures
Jiří 'erný and others
Eukaryotic initiation factor eIF3 facilitates loading of eukaryotic release factor eRF1 or suppressor tRNA to the ribosome
Ekaterina Shuvalova and others
Structural insights into σ
28
-dependent transcription initiation and its regulation by anti-sigma factor in
Pseudomonas aeruginosa
Sheenu and others
Structure of
Bacillus subtilis
Ku-mediated DNA synaptic complex
Whan-Jong Kim and others
Bringing the ends together: cryo-EM structures of mycobacterial Ku in complex with DNA define its role in NHEJ synapsis
Joydeep Baral and others
Foliar-applied double-stranded RNA is mobile, transfers to plant pathogens, and triggers RNAi
Christopher A Brosnan and others
Nucleic Acid Enzymes
Structure and function of the RNA polymerase complex of Borna disease virus, a nuclear-replicating non-segmented negative-strand RNA virus
Eric Gibbs and others
Modular determinants of cleavage preference in GIY-YIG nucleases revealed by block-based DNA shuffling and directed evolution
Kurt W Loedige and others
The DinG exonuclease acts as a primary quality controller to remove unprocessed ribosomal RNAs
Karolis Vaitkevičius and Jörgen Johansson
A modified X10-23 DNAzyme that can better access large, structured RNA targets
Connor Nurmi and others
Enhanced SfaTnpB enables single-base-specific, one-pot nucleic acid detection for high-sensitivity diagnostics
Bingrong Xu and others
Differential association of primary and alternative σ factors with RNA polymerase of
Mycobacterium tuberculosis
during transcription elongation
Nilanjana Hazra and Jayanta Mukhopadhyay
Nuc domain electrostatics drive the
trans
cleavage activity of CRISPR'Cas12a
Anthony Newman and others
Nucleic Acid Therapeutics
Argonaute-mediated RNA editing selectively repairs point mutations
Zhiwei Zhang and others
RNA and RNA-protein complexes
Division of labor in trypanosome RNA processing and export through expanded Mex67 paralogs
Samson O Obado and others
ERK phosphorylates HNRNPF to promote the proliferation and suppress the differentiation of embryonic stem cells
Xiaowei Duan and others
Crystal structures of
Caenorhabditis elegans
PUF-3 depict plasticity of RNA recognition that enables germline gene regulation
Yingying Zhang and others
Mechanistic insights into Lin28-dependent oligo-uridylylation of pre-let-7 by TUT4
Xiaojie Han and others
Potyviruses recruit host eIF4A3 to block m
6
A-mediated RNA decay by steric hindrance of viral RNA methylation in plants
Dezhi Peng and others
Binding of Glycyl-tRNA synthetase to Mengovirus RNA stimulates translation
Fabian Droß and others
Initial spliceosomal U4/U6 di-snRNA formation occurs in the cytoplasm of
Saccharomyces cerevisiae
and requires a guard protein mediated quality control
Xiaoxiao Wang and others
Maternal TDP43 orchestrates nuclear speckle assembly and zygotic splicing activation during oocyte-to-embryo transition in mice
Zuo-Qi Deng and others
Synthetic Biology and Bioengineering
Specific killing and resensitization of pathogenic
Escherichia coli
strains carrying
bla
CTX-M-15
beta -lactamase using targeted-antibacterial-plasmids (TAPs)
Elisabeth Derollez and others
Triplex DNA clamp regulates Cas12a activation for ssDNA and RNA sensing
Andrea Celeste Di Pede and others
A unified computational framework for quantitative design and optimization of transcriptional regulation across bacterial species
Tianze Wang and others
Design of bacterial DNT sensors based on computational models
Shir Bahiri Elitzur and others
Methods
SCALE: unsupervised multiscale domain identification in spatial omics data
Behnam Yousefi and others
Single-molecule mechanostructural fingerprinting of nucleic acid conformations
Prakash Shrestha and others
The nuclear cap-binding complex regulates subcellular RNA processing and surveillance of coding and noncoding RNAs
Diep R Ganguly and Brian D Gregory
Microenvironment-aware spatial modeling for accurate inference of cell identity
Qi Liu and others
Accurate detection of somatic single-nucleotide variants from bulk RNA-seq data using RNA-MosaicHunter
August Yue Huang and others
STAN, a computational framework for inferring spatially informed transcription factor activity
Linan Zhang and others
CellMap: precision mapping of cellular landscape in spatial transcriptomics
Hongjia Liu and others
SVCROWS: a user-defined tool for interpreting significant structural variants in heterogeneous datasets
Noah Brown and others
Accurate chromatin marks peak calling with Omnipeak
Oleg Shpynov and Maxim N Artyomov
